价格：220

    货号：03-031-1B

    规格：100ml

    产品名称：Penicillin-Streptomycin Solution, 青链双抗   

        10,000 units/ml Penicillin G Sodium Salt, 10mg/ml Streptomycin Sulfate 

   【产品介绍】

     Penicillin-Streptomycin is an Aminoglycoside-β Lactam antibiotic 

     combination solution. It accords broad-spectrum bactericidal activity 

against both gram-positive and gram-negative bacteria. The Mode of Action (MOA) of Penicillin 

G interferes with the final stage of synthesis of the bacterial cell wall causing disruption of the 

osmotic pressure gradient with ensuing lysis and cell death, whereas the MOA of Streptomycin 

Sulfate modifies the permeability of the cell wall, interferes with prokaryote protein synthesis and

 cellular respiration by irreversibly binding to the 30S ribosome subunit to cause a misreading/miscoding 

of the mRNA.

In essence, this activity freezes the 30S initiation complex (i.e.30S-mRNA-tRNA) and interrupts any

 further progress in the initiation phase to chain-elongating riboome. Both antibiotics, Penicillin, 

a β-Lactam moiety when combined with Streptomycin, an Aminoglycoside moiety, synergistically

 enhance their range of activities and increase their effectiveness as opposed to when utilized on 

an individual basis.

The efficacy of a Penicillin-Streptomycin synergistic combination is accomplished when two individual 

drugs (i.e. both are bactericidal) interfere with different constituents in the bacterial cellular or metabolic 

pathways. The result is an effect greater than could be attributed to additiveaction. In theory, a drug 

affecting the permeability of the cell membrane (i.e. streptomycin), plus a drug affecting the cell wall 

(i.e. penicillin), when used in combination, may be more effective than either drug used alone. In this

 case, there is even evidence of synergism between thetwo-drugs.

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